Erythema multiforme (Stevens-Johnson) precipitated by Fansidar.
نویسندگان
چکیده
The combination of pyrimethamine and suiphonamide is effective prophylaxis against Plasmo&dm falciparum malaria (Lucas et al., 1969) and is specifically recommended for use in areas where chloroquine-resistant malaria is encountered such as Kenya (British National Formulary, 1983). The sulphonamide component of Fansidar is sulfadoxine, and we believe it is this sulphonamide which precipitated the severe Stevens-Johnson form of erythma multiforme in a young, healthy man.
منابع مشابه
Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study.
BACKGROUND It was proposed that Stevens-Johnson syndrome and toxic epidermal necrolysis differed from erythema multiforme majus by the pattern and localization of skin lesions. OBJECTIVE To evaluate the validity of this clinical separation. DESIGN Case-control study. SETTINGS Active survey from 1989 to 1995 of 1800 hospital departments in Europe. PATIENTS A total of 552 patients and 172...
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QUESTION I recently diagnosed an erythema multiforme rash in several patients, two of whom had the major variant, Stevens-Johnson syndrome. Should these patients be managed with corticosteroids? ANSWER In most cases, mild erythema multiforme is self-limited and resolves in 2 to 4 weeks. Stevens-Johnson syndrome is a serious disease that involves the mucous membranes and lasts up to 6 weeks. T...
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Erythema multiforme may be placed on a disease continuum that includes Stevens-Johnson syndrome and toxic epidermal necrolysis. It was first described in 1866 by Hebra as a skin disease with symmetrically distributed red papules, evolving within several days to form annular or iris-like shapes or blisters. The term multiforme described this evolution of primary lesions into different forms. In ...
متن کاملErythema Multiforme and Stevens-Johnson Syndrome (SJS, Erythema Multiforme Major) in Children — Symptoms and Treatment
Stevens-Johnson syndrome is an immune-complex mediated hypersensitivity reaction that can be triggered by infectious etiologies or the use of anticonvulsants, antibiotics or any other drug. The condition is characterized by epidermal necrolysis, separation of the epidermis from the dermis, and the formation of skin blisters and bullae over the face, lips, throat and upper or lower extremities. ...
متن کاملErythema Multiforme and Stevens-Johnson Syndrome (SJS, Erythema Multiforme Major) in Children — Symptoms and Treatment
Stevens-Johnson syndrome is an immune-complex mediated hypersensitivity reaction that can be triggered by infectious etiologies or the use of anticonvulsants, antibiotics or any other drug. The condition is characterized by epidermal necrolysis, separation of the epidermis from the dermis, and the formation of skin blisters and bullae over the face, lips, throat and upper or lower extremities. ...
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 61 713 شماره
صفحات -
تاریخ انتشار 1985